Feeling generally low on energy, noticing your workouts don't have the same "pump" or stamina they used to, or just feeling like your body isn't running as efficiently as it once did — these are different problems on the surface, but they usually trace back to the same three systems: how well blood and oxygen move through your body, how well your heart is supported day to day, and how efficiently your cells actually produce energy at a molecular level.
None of this is only an "aging" story, and none of it is only a "workout supplement" story either. It's really about three connected pathways — circulation, cardiovascular support, and cellular energy production — that all tend to decline gradually and quietly, long before they show up as an obvious problem.
Common reasons people look into this
- Feeling generally tired or sluggish, even with adequate sleep
- Noticing reduced stamina, endurance, or "pump" during exercise compared to a few years ago
- Wanting to proactively support heart health and healthy circulation, especially alongside statins or as part of general prevention
- Interest in the science around NAD+, cellular aging, and longevity
- Looking for a stimulant-free way to support energy, rather than relying on caffeine or pre-workout blends
What's actually going on
Energy, circulation, and heart health aren't three separate systems so much as three angles on the same underlying picture. Nitric oxide is a molecule your body produces to help blood vessels relax and widen, which is central to how efficiently oxygen and nutrients reach your muscles and tissues — natural production of it tends to decline with age. CoQ10 is a compound your cells rely on directly to produce energy, and it's also concentrated in heart tissue specifically because the heart is one of the most energy-demanding muscles in the body; it's also worth knowing that statins, commonly prescribed for cholesterol, can deplete natural CoQ10 levels. And NAD+ is a molecule every cell needs for energy production and cellular repair, which declines significantly with age — NMN is the direct precursor your body converts into NAD+.
Put together: circulation determines how well oxygen and nutrients get delivered, CoQ10 and cellular energy determine how efficiently your cells (including heart muscle) use what's delivered, and NAD+ underpins the basic energy-and-repair machinery inside every cell. A gap in any one of these can show up as the same vague symptom — low energy, reduced stamina, feeling like you're not quite running at full capacity.
Comparing the three pathways
| Pathway | What it does | Where it shows up |
|---|---|---|
| Nitric oxide (L-arginine, L-citrulline, beetroot) | Supports vasodilation — blood vessels relaxing and widening — for better blood flow | Circulation, exercise stamina, "pump" during training |
| CoQ10 | A compound your cells use directly to generate energy; concentrated in heart tissue | Heart health, general energy, especially relevant if you take statins |
| NAD+ (via NMN) | A molecule every cell needs for energy production and cellular repair; declines with age | Cellular energy, healthy aging, longevity |
They work through genuinely different mechanisms, which is why people often ask about more than one at a time rather than picking just one.
Why Evernate formulates it this way
Evernate's Nitric Oxide Formula combines L-arginine, L-citrulline, and beetroot specifically because they support nitric oxide production through two separate pathways — the amino acids directly and indirectly build arginine levels, while beetroot's dietary nitrates work through an entirely separate route — so the formula covers more ground than any single ingredient alone. The Heart Health & Energy formula pairs 200mg of CoQ10 (as ubiquinone, the stable form the body converts into the active ubiquinol) with beetroot, vitamin D3, and K2, taken with a meal since all three are fat-soluble. And the NAD+ Booster is a single-ingredient, third-party verified 99.6%-pure 600mg NMN capsule — deliberately kept simple, with no blends or fillers, since NMN's dosing and purity are the two things people researching it care most about getting right.
Frequently asked questions
Do I need all three, or should I pick one?
It depends on what you're trying to support. If exercise performance and circulation are the main goal, the Nitric Oxide Formula is the most direct fit. If heart health and statin-related CoQ10 depletion are the concern, Heart Health & Energy is more targeted. If cellular aging and longevity are the focus, NMN addresses that specifically. Many people combine the Nitric Oxide Formula with either of the others since circulation support pairs naturally with both heart health and cellular energy goals.
Is nitric oxide support the same thing as pre-workout?
No. Most pre-workouts rely on caffeine and other stimulants for a quick energy hit. Nitric oxide support works on blood flow and circulation instead, which is why it's stimulant-free and can be taken any time of day, not just before training.
I take a statin — is CoQ10 relevant to me?
Statins are known to deplete the body's natural CoQ10 levels, which is one of the most common reasons people start looking into CoQ10 supplementation. If you take statins, blood thinners, or other heart medication, check with your doctor before adding any new supplement.
What's the actual difference between NAD+ and NMN?
NAD+ is the molecule your cells use directly for energy production and repair, but it can't be taken as an oral supplement effectively. NMN is the precursor your body converts into NAD+, which is why NMN — not NAD+ itself — is the form typically supplemented.
How long before I notice a difference?
This varies by goal. Circulation and exercise-related effects are sometimes noticed within days to a couple of weeks of consistent use. Heart health and cellular-aging support are slower, cumulative processes best thought of in terms of months of consistent daily use, not an immediate effect.
Are these safe to take together?
Generally yes — they work through different mechanisms and are commonly combined. As with any supplement, check with your doctor first if you're pregnant, nursing, taking medication (especially statins, blood thinners, or blood-pressure medication), or managing a medical condition.
Ready to look at the actual formulas? Nitric Oxide Formula, Heart Health & Energy, and NAD+ Booster (NMN 600mg) are all third-party tested and made in Canada.
You may also be researching:
- Nitric Oxide 101: What It Is and How to Boost It Naturally
- CoQ10, Beetroot & Nitrates: How They Support Heart Health and Circulation
- NAD+ and NMN, Explained: What the Research Says About Cellular Energy and Aging
- Morning or Night? When to Take CoQ10, NMN, and Nitric Oxide Support
Sleep & Stress Relief also connects here — chronic stress and poor sleep both affect energy levels and cardiovascular health.